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You can. Twenty Twenty-Five is a native block theme with full site editing (FSE), and the WordPress Query Loop block is built into core — no plugins needed. You can filter by category and tag directly in the block settings.
So the setup would be the same idea: project categories, content-type tags, and Query Loop blocks on your project pages filtering by the right combinations. You just do the layout and template editing through the Site Editor instead of the Customizer.
The advantage over GeneratePress is zero dependencies — it ships with WordPress, gets updated by the core team, and you don’t need GenerateBlocks or any plugin for the query loops.
The tradeoff is that FSE/block themes can feel clunkier to style precisely, and there’s less community documentation for specific use cases compared to GeneratePress. But for a simple research group site with a few project pages and filtered post lists, Twenty Twenty-Five is perfectly capable.
If keeping things minimal and dependency-free matters to you, stick with Twenty Twenty-Five and skip the extra theme/plugin layer entirely.